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PHILADELPHIA, February 22, 2024 (Newswire.com)
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Gratz College is launching the first Master of Arts degree program in Antisemitism Studies in the United States in Fall 2024. This ground-breaking program will help fill the vacuum of knowledge about antisemitism across Jewish, non-Jewish, and governmental organizations responsible for generating policy to combat prejudice at a time of unprecedented Jew hatred.
It will:
• Provide an academic home for those seeking to develop both a deep theoretical and practical understanding of antisemitism;
• Help generate new and impactful research on the factors that contribute to growing antisemitism and test interventions that can successfully combat it; and
• Arm educators and practitioners with the most effective antisemitism pedagogy and programming.
Through degree concentrations in teaching, advocacy and research, graduates of this program will be uniquely qualified for prominent careers in education, think tanks, government relations, public policy, and community organizations (Jewish and non-Jewish).
Pennsylvania Governor Josh Shapiro is eager to see this program take shape:
“We’re seeing a dangerous rise in antisemitism, hatred, and bigotry across our country – and it’s more important than ever that Pennsylvanians be equipped with a thorough knowledge of our shared history and the skills to discern fact from fiction. Gratz College is already renowned for its Holocaust and Genocide Studies programs, and I am encouraged the College is expanding upon that work with a new Master’s degree in Antisemitism Studies. I wish the faculty, staff, and especially the inaugural class of Antisemitism Studies students, great success in their work.”
The program is directed by Dr. Ayal Feinberg, antisemitism studies expert and Director of the Center for Holocaust Studies and Human Rights at Gratz College. The program boasts a distinguished interdisciplinary faculty from academia and leading public advocacy organizations. Despite its infancy, the degree has been endorsed by nearly one hundred scholars and public policy experts from around the world. Professor of Political Science at Kalamazoo College R. Amy Elman asserts, “With an emphasis on operationalizing knowledge, informed teaching and ethical advocacy, Gratz’s innovative graduate program fulfills a deep need in countering antisemitism.”
Gratz’s Antisemitism Studies program is also establishing ground-breaking partnerships with the world’s most prominent Jewish organizations and programs to combat antisemitism in the classroom, on campus, and in professional workspaces. In the first such partnership, Gratz and The Weitzman National Museum of American Jewish History have joined forces to launch the National Education Fellowship on Antisemitism. The aim of this fellowship is to generate and assess paradigm-shifting middle and high school curriculum to reduce Jew-hatred and prejudice more broadly.
On March 4, 2024, the master’s degree program will kick-off with a series of public lectures, including by scholars serving as affiliate faculty for the program. On April 2, 2024, Dr. Avinoam Patt, inaugural director of NYU’s Center for Study of Antisemitism and the Maurice Greenberg Professor of Holocaust Studies, will deliver a keynote lecture, titled, "Awake My People": Jewish Responses to Antisemitism in the Modern Period.” Additional talks will take place before the program officially begins in August.
Prospective students eager to start may apply now and take courses as early as March 2024 with electives in Antisemitism Studies already developed as a preview to the program.
Gratz College is grateful to the Isidore and Penny Myers Foundation for generously supporting the launch of the Antisemitism Studies program. Jay Myers, Board Chair, shared: “The Isidore and Penny Myers Foundation, a family foundation guided by Jewish American values, sees great worth in educating future generations about the roots of Antisemitism, and by doing so, working to combat it. This degree program will create scholars who can devote their talent to meet this challenge. Our Foundation is proud to support this work and by so doing, meet our obligation to help repair the world.”
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With $3.5 million in funding from the GI Research Foundation, a team at the MD Anderson Cancer Center explores a one-two punch to combat BRAF-mutated colorectal cancer and its “dismal prognosis.”
CHICAGO, December 13, 2023 (Newswire.com)
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Many cancers caused by the mutation of the BRAF gene respond well to a class of immunotherapies known as BRAF-inhibitors. BRAF-mutated colorectal cancer, however, almost never does. Doctors have known this for years, but they are yet to find a treatment that works well for most patients.
“BRAF-inhibitors provide very different clinical outcomes,” said Dr. Scott Kopetz, a Professor and Associate Vice President for Translational Integration at The University of Texas MD Anderson Cancer Center. “They work amazingly well in melanoma, for example, but are less effective in colorectal cancer.”
“BRAF [in colorectal cancer] is that odd uncle who doesn’t behave like the rest of the family. The black sheep. Is he even related? The usual rules don’t apply.”
Dr. Kopetz and his team’s most recent studies of this black sheep are now moving from research in mice to clinical trials in humans. These trials were approved by the National Cancer Institute in October and will launch in early 2024.
The GI Research Foundation helped support the work with mice models, along with several other aspects of the team’s BRAF-related research. The $3.5 million grant is part of the foundation’s massive CA CURE initiative.
“Last year, we were able to deliver more than $18 million to researchers across the country to improve diagnostics and develop immunotherapies and personalized vaccines in gastrointestinal cancers through CA CURE,” said Katie Chudnovsky, chair of the GI Research Foundation’s Board of Directors. “Patients need treatments like those being developed by Dr. Kopetz – so very urgently – and we are thrilled to see this team’s work moving to clinical trials so quickly.”
BRAF-mutated colorectal cancer comes with a “dismal prognosis,” according to research in the International Journal of Molecular Sciences, and the median patient survives less than a year.
This new form of treatment for BRAF-mutated colorectal cancer relies on what Kopetz called a “two-hit hypothesis.” That is, these cancers are caused by the combination of mutations in the BRAF gene and epigenetic dysregulation. Epigenetic dysregulation refers to the fact that behaviors and environment can impact how a person’s genes behave.
Here, researchers have found that a mutation to the BRAF gene changes the production of proteins that cause healthy cells to grow into cancerous tumors. Other forms of BRAF-mutated cancer respond well to BRAF-inhibitor immunotherapy that can halt the production of those proteins.
In BRAF-mutated colorectal cancer, however, another piece of DNA is unable to express itself entirely. Those genes typically create natural tumor suppressors that fight early cancer growth. Carbon molecules called methyl groups attach themselves to the DNA and prevent the DNA from building cancer-suppressing proteins. That “methylation” is the epigenetic dysregulation in this case, likely caused by inflammation, diet, or external environmental factors.
If doctors can stop the proteins that cause cancer and stop the bromodomains, they might be able to produce a one-two punch to combat their double hit hypothesis. The treatment would slow BRAF-mutated colorectal cancer growth and encourage natural cancer suppressors.
That idea will be tested in the human trials that were recently approved by the National Cancer Institute. A BRAF-inhibitor, an EGFR-inhibitor, and a bromodomain-inhibitor will be administered to patients. This combined treatment was developed by Kopetz and his colleague Dr. Kunal Rai, an Associate Professor of Genomic Medicine at MD Anderson.
The research moved from the GI Research Foundation-funded mouse models to human trials exceptionally quickly, according to Kopetz.
“It’s rare for the pieces to come together like this,” he said. “Lots of times, this would be two years of work to get the human trials up and running. But we were able to show how clearly this approach worked in multiple mouse models and that really sped things up.”
Other funding from the GI Research Foundation will help speed things up even further. “The new technologies and techniques that Dr. Kopetz and his team are exploring will give them the ability to innovate that much faster. It provides the entire community with the means to gather high-quality data more quickly and get it into trials and ultimately into the clinic,” said Dr. David Rubin. Rubin is the Joseph B. Kirsner Professor of Medicine and Chief of the Section of Gastroenterology, Hepatology and Nutrition at University of Chicago Medicine. He is also GI Research Foundation’s Senior Scientific Advisor.
“The GI Research Foundation has a legacy of funding high risk-high reward and innovative science, and doing so efficiently and extraordinarily effectively. Kopetz and his colleagues were recipients of a dedicated campaign that we launched in 2022 to tackle the most difficult challenges of colorectal cancer.”
“Support from the GI Research Foundation allows us to accelerate our work and try some out of the box stuff,” Kopetz said. “We have amazing animal models, but there’s no substitute for understanding cancer and treatments with the patients themselves. We want to develop the tools we need so we can learn as much as possible from them and help them as much and as quickly as we can.”
About the GI Research Foundation
The GI Research Foundation was founded in 1961 by grateful patients and friends of the late Dr. Joseph B. Kirsner, a pioneer in gastroenterology who devoted his life to medicine, teaching, and patient care. Today, the University of Chicago Medicine’s Digestive Diseases Center, which is supported by the foundation, is internationally recognized for research-driven medicine and its team of highly specialized physicians. For more information, see: https://giresearchfoundation.org/
About the University of Chicago Digestive Diseases Center
The Digestive Diseases Center at the University of Chicago Medicine is a collaborative, multidisciplinary network of physicians, researchers and affiliated health professionals who share a legacy of innovation and a common purpose: to improve the lives of patients who suffer from digestive diseases. For more information, see: https://www.uchicagomedicine.org/conditions-services/digestive-diseases
Contact Information:
Jackie Casey
Executive Director jcasey@girf.org
312-332-1350
COLUMBIA, S.C., December 13, 2023 (Newswire.com)
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